Introducing the First Ever Thermal Insulated Envelope with Integrated PCM Refrigerants

For Room Temperature (CRT) Shipments

Pre-qualified CRT parcel envelope provides temperature stability for last-mile pharmaceutical delivery without needing a cooler and separate gel packs

tempaid pcm envelope trio2

The increasing demand for temperature-controlled packaging necessitates a lower-cost solution that is cost-effective and better for the environment.

The first-of-its-kind thermal insulated shipping mailer integrates PCM refrigerants into its construction, allowing specialty pharma and mail-order drug organizations to send individual doses of medications at a stable room temperature with an envelope form factor. The patent pending solution removes the need for EPS coolers, a corrugated box, and separate refrigerants by integrating a proprietary phase change material (PCM) into the lining of the  envelope:

  • Reduces shipping costs and minimizes the space required for shipments
  • Reduces pack-out error by simplifying the packing process since there is only one fully cohesive component
  • Decreases waste as no cooler or corrugate box is required
  • Envelopes are vacuum sealed and shipped in compressed bundles, which allows companies to stock inventory with ease until ready to use

PCM Refrigerant Built into The Envelope

The thermal insulated mailers contain a Phase Change Material (PCM) selected for the specific temperature it maintains when transitioning between its solid and liquid states. 

For example, the summer mailer incorporates a 23°C PCM which will change from solid to liquid to protect from extreme heat, while the winter mailer utilizes a 5°C PCM which will change from liquid to solid to protect from extreme cold.

Durable Construction with 3 Layers of Protection

The patent-pending, layered construction consists of three protective materials:

  • Specialized PCM mats engineered to be flexible, even in their solid state, control the temperature of the payload
  • Cushioning polyurethane (PU) insulation provides thermal and compression resistance for the product
  • A durable, protective envelope protects the contents from physical damage during transit

Qualified To the ISTA 7D and 7E Standard for URAC Requirements

Controlled room temperature (CRT) regulations and requirements are traditionally defined as 20–25°C, with allowable excursions of 15–30°C, as long as their mean kinetic temperature remains in the specified range. 

Recent URAC requirements have a potential CRT range of 2-30°C if the drug stability supports it per USP 659.

Each mailer is tested against the ISTA 7D & 7E Summer and Winter profiles (as well as Spring/Fall seasonal conditions) using lane data gathered from real-world conditions and tested with several different product payload boxes and instrumented with calibrated RTD temperature monitors.

Quick Specs


Profiles AvailableISTA 7D & 7E: Summer & Winter; Spring/Fall
Available Sizes
Outer DimensionsInner Dimensions
9” x 12 x 3″
11″ x 14” x 3″
12” x 16” x 3″
14” x 18” x 3″
4” x 3″ x 1.5″”
5” x 4” x 2””
7” x 5″ x 2″”
9” x 7″ x 2″
Qualified CRT Temperature Ranges

15°C – 25°C for 48 hours (Summer)

2°C – 30°C for 144 hours (Summer, Winter and Spring/Fall)

Custom ranges available upon request

CustomizableCustom branding available
Unit Weight2 pounds
ShippingShipped in vacuum compressed bundles to enable less storage space

This product is patent pending


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